Publications

Khan IA, Hwang S, Moretto MM.
Toxoplasma gondii: CD8 T Cells Cry for CD4 Help
Front. Cell. Infect. Microbiol. 2019 May;9:136.

Khan IA, Ouellette C, Chen K, Moretto MM.
Toxoplasma: Immunity and Pathogenesis.
Curr Clin Micro Rpt. 2019 Mar;6(1):44. Epub 2019 Feb 4.

Moretto MM, Hwang S, Khan IA.
Downregulated IL-21 Response and T Follicular Helper Cell Exhaustion Correlate with Compromised CD8 T Cell Immunity during Chronic Toxoplasmosis.
Front Immunol. 2017 Oct 31;8:1436. eCollection 2017.

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Hwang S, Cobb DA, Bhadra R, Youngblood B, Khan IA.
Blimp-1-mediated CD4 T cell exhaustion causes CD8 T cell dysfunction during chronic toxoplasmosis.
J Exp Med. 2016 Aug 22;213(9):1799-818. Epub 2016 Aug 1.

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Hwang S, Cobb DA, Bhadra R, Youngblood B, Khan IA.
Blimp-1-mediated CD4 T cell exhaustion causes CD8 T cell dysfunction during chronic toxoplasmosis.
J Exp Med. 2016 Aug 22;213(9):1799-818. Epub 2016 Aug 1.

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Moretto MM, Harrow DI, Hawley TS, Khan IA.
Interleukin-12-Producing CD103+ CD11b- CD8+ Dendritic Cells Are Responsible for Eliciting Gut Intraepithelial Lymphocyte Response against Encephalitozoon cuniculi.
Infect Immun. 2015 Dec;83(12):4719-30. Epub 2015 Sep 28.

Moretto MM, Khan IA.
IL-21 Is Important for Induction of KLRG1+ Effector CD8 T Cells during Acute Intracellular Infection.
J Immunol. 2015 Nov 23. pii: 1501258. [Epub ahead of print]

Moretto MM, Harrow DI, Khan IA.
Effector CD8 T cell immunity in microsporidial infection: a lone defense mechanism.
Semin Immunopathol. 2015 May;37(3):281-7. 

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Bhadra R, Moretto MM, Castillo JC, Petrovas C, Ferrando-Martinez S, Shokal U, Leal M, Koup RA, Eleftherianos I, Khan IA.
Intrinsic TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attrition. 
J Clin Invest. 2014 Jun2;124(6):2441-55.

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Bhadra R, Cobb DA, Khan IA.
Donor CD8+ T cells prevent Toxoplasma gondii de-encystation but fail to rescue the exhausted endogenous CD8+ T cell population. 
Infect Immun. 2013 Sep;81(9):3414-25.

Bhadra R, Cobb DA, Weiss LM, Khan IA.
Psychiatric disorders in toxoplasma seropositive patients--the CD8 connection. 
Schizophr Bull. 2013 May;39(3):485-9.

Bhadra R, Cobb DA, Khan IA.
CD40 signaling to the rescue: A CD8 exhaustion perspective in chronic infectious diseases.
Crit Rev Immunol. 2013;33(4):361-78

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Didier ES, Sugimoto C, Bowers LC, Khan IA, Kuroda MJ.
Immune correlates of aging in outdoor-housed captive rhesus macaques (Macaca mulatta).
Immun Ageing.2012 Nov 14;9(1):25.

Bhadra R, Khan IA.
IL-7 and IL-15 do not synergize during CD8 T cell recall response against an obligate intracellular parasite.
Microbes Infect. 2012 Nov;14(13):1160-8.

Gigley JP, Bhadra R, Moretto MM, Khan IA.
T cell exhaustion in protozoan disease. 
Trends Parasitol. 2012 Sep;28(9):377-84. Review.

Bhadra R, Gigley JP, Khan IA.
PD-1-mediated attrition of polyfunctional memory CD8+ T cells in chronic toxoplasma infection.
J Infect Dis. 2012 Jul1;206(1):125-34.

Bhadra R, Khan IA.
Redefining chronic toxoplasmosis--a T cell exhaustion perspective.
PLoS Pathog. 2012;8(10):e1002903.

Moretto MM, Khan IA, Weiss LM.
Gastrointestinal cell mediated immunity and the microsporidia.
PLoS Pathog. 2012;8(7):e1002775.

Bhadra R, Gigley JP, Khan IA.
Cutting edge: CD40-CD40 ligand pathway plays a critical CD8-intrinsic and -extrinsic role during rescue of exhausted CD8 T cells. 
J Immunol. 2011 Nov 1;187(9):4421-5.

Bhadra R, Gigley JP, Khan IA.
The CD8 T-cell road to immunotherapy of toxoplasmosis. 
Immunotherapy. 2011 Jun;3(6):789-801. Review.

Bhadra R, Gigley JP, Weiss LM, Khan IA.
Control of Toxoplasma reactivation by rescue of dysfunctional CD8+ T-cell response via PD-1-PDL-1 blockade.
Proc Natl Acad Sci U S A. 2011 May 31;108(22):9196-201.

Khan IA, Lupi M, Campbell L, Chappell SC, Brown MR, Wiltshire M, Smith PJ, Ubezio P, Errington RJ.
Interoperability of time series cytometric data: a cross platform approach for modeling tumor heterogeneity.
Cytometry A. 2011 Mar;79(3):214-26.

Gigley JP, Bhadra R, Khan IA.
CD8 T Cells and Toxoplasma gondii: A New Paradigm. 
J Parasitol Res. 2011;2011:243796.

Gigley JP, Khan IA.
Plasmacytoid DC from aged mice down-regulate CD8 T cell responses by inhibiting cDC maturation after Encephalitozoon cuniculi infection.
PLoS One. 2011;6(6):e20838.

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Didier ES, Bowers LC, Martin AD, Kuroda MJ, Khan IA, Didier PJ.
Reactive nitrogen and oxygen species, and iron sequestration contribute to macrophage-mediated control of Encephalitozoon cuniculi (Phylum Microsporidia) infection in vitro and in vivo.
Microbes Infect. 2010 Dec;12(14-15):1244-51.

Lawlor EM, Moretto MM, Khan IA.
Optimal CD8 T-cell response against Encephalitozoon cuniculi is mediated by Toll-like receptor 4 upregulation by dendritic cells.
Infect Immun. 2010 Jul;78(7):3097-102.

Moretto MM, Lawlor EM, Xu Y, Khan IA, Weiss LM.
Purified PTP1 protein induces antigen-specific protective immunity against Encephalitozoon cuniculi. 
Microbes Infect. 2010 Jul;12(7):574-9.

Moretto MM, Lawlor EM, Khan IA.
Lack of interleukin-12 in p40-deficient mice leads to poor CD8+ T-cell immunity against Encephalitozoon cuniculi infection.
Infect Immun. 2010 Jun;78(6):2505-11.

Bhadra R, Guan H, Khan IA.
Absence of both IL-7 and IL-15 severely impairs the development of CD8 T cell response against Toxoplasma gondii. 
PLoS One. 2010 May 26;5(5):e10842.

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Moretto MM, Lawlor EM, Khan IA.
Aging mice exhibit a functional defect in mucosal dendritic cell response against an intracellular pathogen.
J Immunol. 2008 Dec 1;181(11):7977-84.

Khan IA, Hakak R, Eberle K, Sayles P, Weiss LM, Urban JF Jr.
Coinfection with Heligmosomoides polygyrus fails to establish CD8+ T-cell immunity against Toxoplasma gondii.
Infect Immun. 2008 Mar;76(3):1305-13.

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Wei S, Daniel BJ, Brumlik MJ, Burow ME, Zou W, Khan IA, Wadsworth S, Siekierka J, Curiel TJ.
Drugs designed to inhibit human p38 mitogen-activated protein kinase activation treat Toxoplasma gondii and Encephalitozoon cuniculi infection.
Antimicrob Agents Chemother. 2007 Dec;51(12):4324-8.

Moretto MM, Weiss LM, Combe CL, Khan IA.
IFN-gamma-producing dendritic cells are important for priming of gut intraepithelial lymphocyte response against intracellular parasitic infection. 
J Immunol. 2007 Aug 15;179(4):2485-92.

Guan H, Moretto M, Bzik DJ, Gigley J, Khan IA.
NK cells enhance dendritic cell response against parasite antigens via NKG2D pathway. 
J Immunol. 2007 Jul1;179(1):590-6.

Khan IA.
Toll road for Toxoplasma gondii: the mystery continues.
Trends Parasitol. 2007 Jan;23(1):1-3.

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Khan IA, Thomas SY, Moretto MM, Lee FS, Islam SA, Combe C, Schwartzman JD, Luster AD.
CCR5 is essential for NK cell trafficking and host survival following Toxoplasma gondii infection.
PLoS Pathog. 2006 Jun;2(6):e49.

Combe CL, Moretto MM, Schwartzman JD, Gigley JP, Bzik DJ, Khan IA.
Lack of IL-15 results in the suboptimal priming of CD4+ T cell response against an intracellular parasite.
Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6635-40.

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Combe CL, Curiel TJ, Moretto MM, Khan IA.
NK cells help to induce CD8(+)-T-cell immunity against Toxoplasma gondii in the absence of CD4(+) T cells.
Infect Immun. 2005 Aug;73(8):4913-21.

Kelly MN, Kolls JK, Happel K, Schwartzman JD, Schwarzenberger P, Combe C, Moretto M, Khan IA.
Interleukin-17/interleukin-17 receptor-mediated signaling is important for generation of an optimal polymorphonuclear response against Toxoplasma gondii infection.
Infect Immun. 2005 Jan;73(1):617-21.

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Stoicov C, Whary M, Rogers AB, Lee FS, Klucevsek K, Li H, Cai X, Saffari R, Ge Z, Khan IA, Combe C, Luster A, Fox JG, Houghton J.
Coinfection modulates inflammatory responses and clinical outcome of Helicobacter felis and Toxoplasma gondii infections.  J
Immunol. 2004 Sep 1;173(5):3329-36.

Moretto M, Weiss LM, Khan IA.
Induction of a rapid and strong antigen-specific intraepithelial lymphocyte response during oral Encephalitozoon cuniculi infection.
J Immunol. 2004 Apr 1;172(7):4402-9.

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Khan IA, Moretto M, Wei XQ, Williams M, Schwartzman JD, Liew FY.
Treatment with soluble interleukin-15Ralpha exacerbates intracellular parasitic infection by blocking the development of memory CD8+ T cell response.
J Exp Med. 2002 Jun3;195(11):1463-70.

Casciotti L, Ely KH, Williams ME, Khan IA.
CD8(+)-T-cell immunity against Toxoplasma gondii can be induced but not maintained in mice lacking conventional  CD4(+) T cells.
 Infect Immun. 2002 Feb;70(2):434-43.

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